WebHere, we have identified both resistance and fitness-compensatory mutations in EF-G of S. aureus. Our data suggest that compensatory evolution to reduce the fitness costs associated with antibiotic resistance is a frequent occurrence in the clinical environment. Results Identification of fusidic acid resistance mutations WebSep 13, 2024 · Compensatory evolution took two alternative routes: either hosts evolved higher symbiont loads to mitigate for their new algal symbiont’s poor performance, or the algal symbionts themselves evolved higher investment in photosynthesis and photoprotective traits to better mitigate light stress. These findings suggest that partner …
Compensatory vs. pseudocompensatory evolution in molecular …
WebAug 22, 2024 · To characterize the molecular basis of compensatory evolution in phage-resistant bacteria, we first considered that compensatory mutations in other systems are often related to biochemical protein stability or specialized protein-protein interactions (Bridgham et al. 2009; Gong et al. 2013). We therefore predicted that different … WebJun 1, 2024 · Compensatory evolution following gene loss was rapid and pervasive: 68% of the genotypes reached near wild-type fitness through accumulation of adaptive … the nba budget mouthly
Transcriptome and translatome co-evolution in …
WebAug 29, 2011 · Here, by specifically discriminating two distinct types of cis-transcompensation, we show, based on stochastic simulations, that compensatory regulatory evolution under stabilizing selection could reduce heterospecific binding and therefore explain the hypothetical increase in the relative contribution of cis-regulatory … WebModel of the compensatory dynamics of low-complexity regions and gene paralogy in species evolution. ( A) There is an attractor of functions evolving without the need for … WebJun 1, 2024 · This mitonuclear compensatory coevolution hypothesis proposes that products of the nuclear (N) genome evolve novel features, enabling them to alleviate or nullify the dysfunctions that would otherwise be caused by deleterious alleles in … the nba cba