WebMutations in positions 193, 197, 203 and 204 of the linker IDR have been mapped to the loops connecting disordered and structured regions [76], implicating these sites in … WebApr 9, 2024 · HIGHLIGHTS. who: Mariane Gonu00e7alves-Kulik et al. from the Institute of Organismic and Molecular Evolution, Faculty of Biology, Johannes Gutenberg University …
Computational Methods to Predict Intrinsically Disordered Regions …
WebJul 2, 2024 · Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part … WebAug 30, 2024 · Consistently, we found that the C-terminal domain of kazrin C, predicted to be an Intrinsically Disordered Region (IDR), directly interacts with several components … sims catheter
Intrinsically Disordered Proteins in Replication Process
WebTranscription factors (TFs) bind only a subset of their motif-containing promoters. Brodsky and Jana et al. find that promoter selection is dictated by multiple specificity determinants distributed across long intrinsically disordered regions (IDRs) encoded within the TF sequence. IDR-guided specificity may accelerate binding-site recognition by an initial … WebIntrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence gene regulation, ... We use DisP-seq to analyze cancer cells and reveal how disordered protein-associated islands enable IDR-dependent mechanisms that control the binding and function of disordered TFs, ... WebBiomolecular condensation via liquid-liquid phase separation of intrinsically disordered proteins/regions (IDPs/IDRs) along with other biomolecules is thought to govern critical … rcog ovarian cysts