WebJul 1, 2016 · Measurements and main results: Fibrotic lung strips responded to tensile force by releasing active TGF-β1 from latent stores with subsequent increase in tissue phospho-Smad2/3. In contrast, measurable active TGF-β1 and phospho-Smad2/3 were not induced by mechanical stress in nonfibrotic lungs. WebThis study aimed to elucidate how HCV infection affected hepatic fibro-carcinogenesis, particularly via phospho-Smad signaling. Methods: We first studied phospho-Smad2/3 …
PathScan® Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425) Sandwich ELISA …
WebJan 1, 2024 · PDGF treated rat hepatic stellate cells rapidly increase the phosphorylation of Smad2/3 threonine residue which was inhibited in the presence of a Jnk antagonist. In … WebOct 7, 2024 · Labeling was performed by incubating cells for 1 h with specific antibodies for SMAD2/3, vinculin and phospho-FAK Y397. After three PBS 1x washes, cells were incubated with the specific secondary ... greenleaf alf orlando
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WebJan 15, 2003 · To address possible mechanisms whereby ATRA might decrease levels of phospho-Smad2/3 in cells treated with TGF-β1, we investigated whether either … WebJul 8, 2024 · Total Smad2/3 levels were relatively constant across gestation while the ratio of active phosphorylated forms to their total levels varied with gestational stages, with a higher pSmad2/total Smad2 in later gestation and a higher pSmad3/total Smad3 in early gestation. ... ERK has been shown to increase Smad2 signaling but inhibit Smad3 activity ... WebAs shown in Figure 6B through 6G, a noteworthy increase in TGF-β, α-SMA, p-Smad2, and p-Smad3 expression and a remarkable reduction in Smad7 expression were discovered in the fibrotic myocardium of WT mice after TAB. Additionally, SAA1 deficiency alleviated TGF-β, α-SMA, p-Smad2, and p-Smad3 expression and promoted Smad7 protein levels ... fly for white guy